abstract：PURPOSE:Serum thyrotropin (TSH) is a well-established growth factor for thyroid nodules and suppression of TSH concentrations by administering exogenous thyroxine may interfere with the growth of established nodules as well as the formation of new thyroid nodules. The aim of this study was to investigate whether serum ...

journal_title：Journal of cancer research and clinical oncology

authors： Polyzos SA,Kita M,Efstathiadou Z,Poulakos P,Slavakis A,Sofianou D,Flaris N,Leontsini M,Kourtis A,Avramidis A

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:The clinical assessment of the myocardial damage caused by anthracyclin (ANT)-therapy is difficult. Therefore a study was performed to evaluate non-invasive markers of anthracyclin-induced cardiac effects, with emphasis on course-to-course variation. METHODS:Eligible for study participation were patients,...

journal_title：Journal of cancer research and clinical oncology

authors： Broeyer FJ,Osanto S,Ritsema van Eck HJ,van Steijn AQ,Ballieux BE,Schoemaker RC,Cohen AF,Burggraaf J

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1), one of TGF-beta superfamily gene, is reported to be responsible for NSAID-induced apoptosis. We analyzed NAG-1 expression in gastric cancer and adenoma to find out its clinical implication. METHODS:Immunostaining was performed usin...

journal_title：Journal of cancer research and clinical oncology

authors： Park JY,Park KH,Bang S,Kim MH,Koh SS,Song SY

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Metastasizing epithelioid sarcoma (ES) is an extremely aggressive tumor, because conventional chemotherapy and irradiation are largely ineffective. Here, we analyzed the impact of the CD95-mediated drug-induced apoptosis in ES cell lines. METHODS:The effects of paclitaxel (Taxol) and 5-FU were determined by MT...

journal_title：Journal of cancer research and clinical oncology

authors： Heikaus S,Matuszek KS,Suschek CV,Ramp U,Reinecke P,Grinstein E,Haremza J,Gabbert HE,Mahotka C

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:The gold standard of axillary sentinel lymph node biopsy (SLNB) in breast cancer is the combination of radioactive colloid and blue dye injection. Worldwide, numerous hospitals without access to radioactive tracers still perform a routine complete axillary lymph node dissection (ALND). We retrospectively analyz...

journal_title：Journal of cancer research and clinical oncology

authors： Kavallaris A,Camara O,Runnebaum IB

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Kaposi's Sarcoma (KS) is a malignant neoplasm arising from endothelial cells. HHV8-infection represents a key pathogenic determinant for the development of KS. There are no standard criteria to treat KS in immunosuppressed-individuals. Six cases (2.1%) of KS occurred in our Center among 285-recipients who ...

journal_title：Journal of cancer research and clinical oncology

authors： Di Benedetto F,Di Sandro S,De Ruvo N,Berretta M,Masetti M,Montalti R,Ballarin R,Cocchi S,Potenza L,Luppi M,Gerunda GE

更新日期：2008-06-01 00:00:00

abstract：:To evaluate the epidermal growth factor receptor (EGFR) protein expression, gene mutations and amplification as predictors of clinical outcome in patients with non-small-cell lung cancer (NSCLC) receiving gefitinib, we have performed fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). We investig...

journal_title：Journal of cancer research and clinical oncology

authors： Sasaki H,Endo K,Okuda K,Kawano O,Kitahara N,Tanaka H,Matsumura A,Iuchi K,Takada M,Kawahara M,Kawaguchi T,Yukiue H,Yokoyama T,Yano M,Fujii Y

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To discover new molecular targets for cancer therapy and diagnosis, we surveyed signal transducers and activators of transcription 3 (Stat3)-regulated genes, because constitutive activation of Stat3 is associated with a wide variety of human malignancies. METHODS:We investigated the Stat3-regulated genes in 29...

journal_title：Journal of cancer research and clinical oncology

authors： Tomida M,Ohtake H,Yokota T,Kobayashi Y,Kurosumi M

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Predictive factors for response to docetaxel in human breast cancers have yet to be identified. The aim of the present study was to investigate the relationship of various clinicopathological and biological parameters with pathological response to docetaxel in the neoadjuvant setting. METHODS:The study populat...

journal_title：Journal of cancer research and clinical oncology

authors： Miyoshi Y,Kurosumi M,Kurebayashi J,Matsuura N,Takahashi M,Tokunaga E,Egawa C,Masuda N,Kim SJ,Okishiro M,Yanagisawa T,Ueda S,Taguchi T,Tamaki Y,Noguchi S,Collaborative Study Group of Scientific Research of the Japanese Breas

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:Serum low molecular weight protein biomarkers might be important in relation to portal vein tumor thrombi (PVTT) in hepatocellular carcinoma (HCC). This study aimed to screen and to detect these biomarkers. METHODS:We selected sera of 3 groups from 12 healthy volunteers, 12 HCC patients without PVTT and 12 HCC...

journal_title：Journal of cancer research and clinical oncology

authors： Qiu JG,Fan J,Liu YK,Zhou J,Dai Z,Huang C,Tang ZY

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta1 (TGF-beta1) and its receptor II (TGF-betaRII) are two key components of TGF-beta signaling and play an important role in carcinogenesis. Several functional polymorphisms were identified in TGFB1 and TGFBR2 and associated with elevated serum or plasma level of TGF-beta1 and enhan...

journal_title：Journal of cancer research and clinical oncology

authors： Jin G,Deng Y,Miao R,Hu Z,Zhou Y,Tan Y,Wang J,Hua Z,Ding W,Wang L,Chen W,Shen J,Wang X,Xu Y,Shen H

更新日期：2008-03-01 00:00:00

abstract：:Several large, well-controlled clinical trials have now established that the aromatase inhibitors (AIs), including letrozole, anastrozole, and exemestane, are more effective than tamoxifen when used as adjuvant endocrine therapy in postmenopausal women with breast cancer. Yet, it is an open question as to how these dr...

journal_title：Journal of cancer research and clinical oncology

authors： Paepke S,Jacobs VR,Ohlinger R,Warm M,Kümmel S,Thomas A,Harbeck N,Kiechle-Bahat M

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs. MATERIALS AND ME...

journal_title：Journal of cancer research and clinical oncology

authors： Oikonomou D,Hassan K,Kaifi JT,Fiegel HC,Schurr PG,Reichelt U,Aridome K,Yekebas EF,Mann O,Kluth D,Strate T,Izbicki JR

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to characterize three new, recently established non-Hodgkin lymphoma cell lines (GUMBUS, DOGUM, and DOGKIT), isolated from patients developing high-clinical resistance to cytotoxic therapy, with respect to sensitivity toward 21 antitumor drugs from different classes of action, expressi...

journal_title：Journal of cancer research and clinical oncology

authors： Bracht K,Kiefer T,Dölken G,Bednarski PJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Aim of the present study was to identify the genetic heterogeneity, prevalence and frequency of germline mutations of BRCA2 gene in Hereditary Breast/Ovarian cancer patients from Kerala, South India. METHODS:We analyzed 102 Breast/Ovarian cancer patients from 96 breast and/ovarian cancer families for BRCA2 gen...

journal_title：Journal of cancer research and clinical oncology

authors： Syamala V,Sreeja L,Syamala VS,Vinodkumar B,Raveendran PB,Sreedharan H,Kuttappan R,Balakrishnan L,Ankathil R

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Kinase insert domain-containing receptor (KDR) is one of the molecular targets used in cancer therapy. We studied the KDR expression characteristics and the relationship with the clinical parameters of the patients with lung cancer, to give the basic evidence and clue for tailoring therapy. METHODS:Reverse tra...

journal_title：Journal of cancer research and clinical oncology

authors： An SJ,Nie Q,Chen ZH,Lin QX,Wang Z,Xie Z,Chen SL,Huang Y,Zhang AY,Yan JF,Wu HS,Lin JY,Li R,Zhang XC,Guo AL,Mok TS,Wu YL

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:Putative tumor suppressor genes LATS1 and LATS2 are implicated in the regulation of the cell cycle at the G2/M and G1/S phase, respectively. This study investigated possible correlations of intra-tumoral LATS1 and LATS2 mRNA levels with response to epirubicin plus cyclophosphamide (EC) or docetaxel (DOC) treatm...

journal_title：Journal of cancer research and clinical oncology

authors： Takahashi Y,Miyoshi Y,Morimoto K,Taguchi T,Tamaki Y,Noguchi S

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of a novel low dose chemotherapy as a remission induction regimen for elderly de novo AML patients ineligible for intensive chemotherapy. METHOD:Fifty consecutive patients, aged 60 to 85, with untreated de novo AML were enrolled. Patients with poor PS or defined non-hematolo...

journal_title：Journal of cancer research and clinical oncology

authors： Tsurumi H,Kanemura N,Hara T,Kasahara S,Yamada T,Sawada M,Oyama M,Moriwaki H

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:We aimed to clarify the prognostic impact of the anatomic extent of hepatic resection (Hr) related to the tumor hepatic involvement (H) on patients' survival in the treatment of hepatocellular carcinoma (HCC). METHOD:The 305 patients with HCC who had undergone hepatectomy were analyzed retrospectively. The pat...

journal_title：Journal of cancer research and clinical oncology

authors： Ochiai T,Sonoyama T,Kikuchi S,Okayama T,Konishi H,Kitagawa M,Tagi T,Ueda Y,Otsuji E

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Oxidative stress is considered a risk factor for prostate cancer development and is associated with the production of reactive oxygen species (ROS). The base excision repair gene MYH protects against ROS-mediated damage to DNA. Inherited MYH mutations predispose to colorectal adenomas and cancer. A compromised ...

journal_title：Journal of cancer research and clinical oncology

authors： Shin EJ,Chappell E,Pethe V,Hersey K,van der Kwast T,Fleshner N,Bapat B

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:The functional relationship between promoter hypermethylation and gene inactivation has been demonstrated for few genes only. We examined the promoter methylation status of two important tumor suppressor genes APAF-1 and DAPK-1 in bladder cancer as well as the mRNA expression pattern of these two genes for poss...

journal_title：Journal of cancer research and clinical oncology

authors： Christoph F,Hinz S,Kempkensteffen C,Weikert S,Krause H,Schostak M,Schrader M,Miller K

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To analyse hepcidin serum and urine levels during radiotherapy for prostate cancer. METHODS:In 18 patients undergoing radiotherapy for prostate cancer, blood, plasma, and urine samples were taken before and during radiotherapy. Complete blood cell count, pro-hepcidin-, ferritin-, transferrin-, IL-1beta-, IL-6-...

journal_title：Journal of cancer research and clinical oncology

authors： Christiansen H,Saile B,Hermann RM,Rave-Fränk M,Hille A,Schmidberger H,Hess CF,Ramadori G

更新日期：2007-05-01 00:00:00

abstract：:Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major breakthroughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progres...

journal_title：Journal of cancer research and clinical oncology

authors： Dass CR,Ek ET,Choong PF

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Individuals affected by rheumatoid arthritis (RA) occasionally develop lymphoproliferative disorders (RA-LPD). To study the molecular changes underscoring the RA-LPD, mutations of p53 and Bak gene were analyzed in RA-LPD with (MTX-LPD) or without methotrexate treatment for RA (non-MTX-LPD). METHODS:Histology a...

journal_title：Journal of cancer research and clinical oncology

authors： Xu JX,Hoshida Y,Hongyo T,Sasaki T,Miyazato H,Tomita Y,Aozasa K

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:The high incidence of biliary tract carcinoma in patients with anomalous pancreaticobiliary ductal junction (APBDJ) implicates that a compositional alteration in bile may contribute to the genesis of this cancer. Lysophosphatidylcholine (LPC) is generated in the bile of these patients. Given the role of cycloox...

journal_title：Journal of cancer research and clinical oncology

authors： Gwak GY,Yoon JH,Lee SH,Lee SM,Lee HS,Gores GJ

更新日期：2006-12-01 00:00:00

abstract：:E-cadherin mainly mediated the epithelial cell-cell adhesion, and integrin signaling can modulate the signaling pathway of E-cadherin in the different levels. Up to now, however, it is still unclear that whether E-cadherin could interfere with cell-matrix interaction, a typical adhesion through integrins. In this stud...

journal_title：Journal of cancer research and clinical oncology

authors： Wu H,Liang YL,Li Z,Jin J,Zhang W,Duan L,Zha X

更新日期：2006-12-01 00:00:00

abstract：:To investigate the prevalence of BRCA1 and BRCA2 mutations among Chinese patients, we studied 70 Shanghai cases with early onset breast cancer and affected relatives, and mutation screening was performed in the whole-gene sequence of BRCA1 and BRCA2 by polymerase chain reaction-based denaturing high-performance liquid...

journal_title：Journal of cancer research and clinical oncology

authors： Song CG,Hu Z,Wu J,Luo JM,Shen ZZ,Huang W,Shao ZM

更新日期：2006-10-01 00:00:00

abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

journal_title：Journal of cancer research and clinical oncology

authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

更新日期：2006-06-01 00:00:00

abstract：:Solitary fibrous tumors (SFT) of extremities, especially the thighs are very rare. Despite SFTs are generally benign, well-circumscribed soft tissue tumors new cases should be presented and followed up carefully to monitor their biological behavior. In general for tumor classification a biopsy is state of the art. His...

journal_title：Journal of cancer research and clinical oncology

authors： Anders JO,Aurich M,Lang T,Wagner A

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:The antimalarial agent, artemisinin, also confers cancer-specific cytotoxic effects by reacting with ferrous iron atoms to form free radicals. Here, we investigated the radiosensitizing effects of dihydroartemisinin on glioma cells and assessed some possible mechanisms for these effects. MATERIALS AND METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kim SJ,Kim MS,Lee JW,Lee CH,Yoo H,Shin SH,Park MJ,Lee SH

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Tumour cells killing by cytotoxic therapies largely depends on triggering the intrinsic apoptosome-mediated caspase activation pathway but it had never been evaluated whether the expression of transcripts encoding the core components of apoptosome pathway is altered in non-small cell lung carcinoma (NSCLC). ME...

journal_title：Journal of cancer research and clinical oncology

authors： Krepela E,Procházka J,Fiala P,Zatloukal P,Selinger P

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Her-2/neu and the insulin-like growth factor-1 receptor (IGF-1R) share common postreceptor-signaling pathways, and pre-clinical models have implicated IGF-1R-signaling in resistance to treatment with the anti-Her-2/neu antibody trastuzumab. The present analysis was performed to evaluate the clinical relevance o...

journal_title：Journal of cancer research and clinical oncology

authors： Köstler WJ,Hudelist G,Rabitsch W,Czerwenka K,Müller R,Singer CF,Zielinski CC

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Investigation of cell migration and proliferation of human glioma cell line spheroids (CLS) and evaluation of morphology, apoptosis, and immunohistochemical expression of MIB-1, p53, and p21 of organotypic muticellular spheroids (OMS) following cisplatin (CDDP) and irradiation (RT). MATERIAL AND METHODS:Sphero...

journal_title：Journal of cancer research and clinical oncology

authors： Fehlauer F,Muench M,Rades D,Stalpers LJ,Leenstra S,van der Valk P,Slotman B,Smid EJ,Sminia P

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:To investigate the pattern and level of cyclooxygenase-2 (COX-2) expression in a series of high grade primary and recurrent glioblastoma multiforme (GBM) and correlation with time to recurrence and patients' survival following therapy. The relationship between COX-2 and epidermal growth factor receptor (EGFR) i...

journal_title：Journal of cancer research and clinical oncology

authors： Sminia P,Stoter TR,van der Valk P,Elkhuizen PH,Tadema TM,Kuipers GK,Vandertop WP,Lafleur MV,Slotman BJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To study the interplay of drugs and energy metabolism of tumor cells, metabolic changes induced by chloroacetaldehyde and cytochalasin B were analyzed in colon carcinoma cells LS174T. METHODS:O(2)-consumption and extracellular acidification were recorded using a bioelectronic sensor-chip system, which monitors...

journal_title：Journal of cancer research and clinical oncology

authors： Motrescu ER,Otto AM,Brischwein M,Zahler S,Wolf B

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the impact of cyclin D1 overexpression (considered separately or jointly with previously assessed p53 and pRb statuses) on survival in a group of 111 surgically treated non-small cell lung cancer patients (NSCLC). METHODS:Cyclin D1 accumulation was assessed immunohistochemic...

journal_title：Journal of cancer research and clinical oncology

authors： Dworakowska D,Jassem E,Jassem J,Boltze C,Wiedorn KH,Dworakowski R,Skokowski J,Jaśkiewicz K,Czestochowska E

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of concurrent radiochemotherapy in patients with stage III non-small cell lung cancer (NSCLC), and to examine the effect of hemoglobin levels on survival of those patients. The negative impact of anemia on survival has been noticed for other cancer sites including the head and neck, and...

journal_title：Journal of cancer research and clinical oncology

authors： Pradier O,Lederer K,Hille A,Weiss E,Christiansen H,Schmidberger H,Hess CF

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:T cell transcription factors are nuclear effectors of the Wnt signaling transduction pathway and play crucial roles in embryonic and malignant development. Our previous study showed increased expression level of Tcf mRNA in liver cancer. In the present paper, antisense Tcf RNA was used to explore the possible t...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Y,Zhou XD,Liu YK,Huang XW,Zhao Y,Xue Q,Sun RX,Chen J,Wu X

更新日期：2004-11-01 00:00:00

abstract：:Indirubin, a 3, 2' bisindole isomer of indigo, has originally been identified as the active principle of a traditional Chinese preparation and has been proven to exhibit antileukemic effectiveness in chronic myelocytic leukemia. Indirubin was detected to represent a novel lead structure with potent inhibitory potentia...

journal_title：Journal of cancer research and clinical oncology

authors： Eisenbrand G,Hippe F,Jakobs S,Muehlbeyer S

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Results from in vitro chemosensitivity testing recommend treosulfan/gemcitabine chemotherapy for the treatment of stage IV uveal melanoma. METHODS:Twenty patients received treosulfan 3,500 mg/m2 followed by gemcitabine 1,000 mg/m2 on day 1 and day 8 repeated on day 29. In cases of prior chemotherapy only 75% o...

journal_title：Journal of cancer research and clinical oncology

authors： Terheyden P,Bröcker EB,Becker JC

更新日期：2004-07-01 00:00:00